Axel Lab Publications

1967 Axel, R., I. B Weinstein and E. Farber. Patterns of transfer RNA in normal rat liver and during hepatic carcinogenesis. Proc. Natl. Acad. Sci. USA 58: 1255-1260.

1967 Axel, R., I. B. Weinstein and E. Farber. Patterns of sRNA in mammalian cells. Proc. Amer. Assoc. Cancer. Res. 8:3.

1967 Friedman, S. M., R. Axel, and I. B. Weinstein. Stability of ribosomes and ribosomal RNA in Bacillus Stearothermophilus. J. Bacteriol. 93: 1521-526.

1972 Axel, R., J. Schlom, and S. Spiegelman. Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. Nature 235: 32-36.

1972 Axel, R., J. Schlom, and S. Spiegelman. Evidence for translation of viral-specific RNA in cells of a mouse mammary carinoma. Proc. Natl. Acad. Sci. USA 69: 535-538.

1972 Spiegelman, S., R. Axel, and J. Schlom. Virus-related RNA in human and mouse mammary tumors. J. Natl. Cancer. Inst. 48: 1205-1211.

1972 Gulati, S. C., R. Axel, and S. Spiegelman. Detection of RNA- instructed DNA polymerase and high molecular weight RNA in malignant tissue. Proc. Natl. Acad. Sci. USA 69: 3133-3137.

1972 Axel, R., S. C. Gulati, and S. Spiegelman. Particles containing RNA- instructed DNA polymerase and virus-related RNA in human breast cancers. Proc. Natl. Acad. Sci. USA 69: 3133-3137.

1972 Weinstein, I. B., R. Gebert, U. Stadler, J. Orenstein, and R. Axel. Type C virus from cell cultures of chemically induced rat hepatomas. Science 178: 1098-1100.

1972 Spiegelman, S., R. Axel, W. Baxt, S. C. Gulati, R. Hehlmann, D. Kufe, and J. Schlom. Human Cancer and the RNA Tumor Viruses. In: RNA VIRUSES/RIBOSOMES, North-Holland Publishing Co. Amsterdam, (FEBS SYMPOSIUM), pp. 73-99.

1973 Harter, D., R. Axel, A. Burny, S. C. Gulati, J. Schlom, and S. Spiegelman. The relationship of visna, maedi and RNA tumor viruses as studied by molecular hybridization. Virology 52: 287-291.

1973 Spiegelman, S., R. Axel, W. Baxt, S. C. Gulati, R. Hehlmann, D. Kufe, and J. Schlom. The Relevance of RNA Tumor Viruses to Human Cancer. In: CELLULAR MODIFICATION AND GENETIC TRANSFORMATION BY EXOGENOUS NUCLEIC ACIDS (Roland F. Beers and R. Carmichael Tilghman, eds.) The Johns Hopkins Univ. Press, Baltimore, pp. 282-312.

1973 Spiegelman, S., R. Axel, W. Baxt, S. C. Gulati, R. Hehlmann , D. Kufe, and J. Schlom . Molecular Evidence for a Viral Etiology of Human Cancer. In: GENETICS AND THE CANCER CELL, Seventh National Cancer Conference Proceedings, Los Angeles, Sept. 1972, Lippincott, Philadelphia, pp. 21-40.

1973 Axel, R., H. Cedar, and G. Felsenfeld. Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc. Natl. Acad. Sci. USA 70: 2029-2032.

1973 Cedar, H., R. Axel, and G. Felsenfeld. Structure and Function of the Globin Genes in Chromatin. In: FOGARTY INTERNATIONAL SYMP. 26: 243-256.

1974 Axel, R., H. Cedar, and G. Felsenfeld. Chromatin Template Activity and Chromatin Structure. In: COLD SPRING HARBOR SYMP. QUANT. BIOL. 38: 773 -783.

1974 Spiegelman, S., J. Schlom, R. Axel, R. Hehlmann, and D. Kufe. Molecular Probing for a Viral Etiology of Human Cancer. In: MOLECULAR STUDIES IN VIRAL NEOPLASIA, Univ. of Texas M.D. Anderson Hospital and Tumor Institutes at Houston, 25th Annual Symposium on Fundamental Cancer Research, 1972. The Williams & Wilkins Co., Baltimore, pp. 547- 573.

1974 Spiegelman, S., R. Axel, W. Baxt, D. Kufe, and J. Schlom. Human cancer and animal viral oncology. Cancer 34: 1406-1420.

1974 Axel, R., W. Melchior, B. Sollner-Webb, and G. Felsenfeld. Specific sites of interaction between histones and DNA in chromatin. Proc. Natl. Acad. Sci. USA 71: 4101-4105.

1975 Axel, R., H. Cedar, and G. Felsenfeld. The structure of the globin genes in chromatin. Biochemistry 14: 2489-2495.

1975 Axel, R. Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease. Biochemistry 14: 2921-2925.

1975 Spiegelman, S., R. Axel, W. Baxt, D. Kufe, and J. Schlom. The molecular genetics of human cancer and its etiologic implications. Genetics 79: 317- 378.

1975 Felsenfeld, G., R. Axel, H. Cedar, and B. Sollner-Webb. The Specific Template Activity of Chromatin. In: THE STRUCTURE AND FUNCTION OF CHROMATIN. Ciba Foundation Symposium 28. ASP (Elsevier Excerpta Medica North-Holland) Amsterdam, pp. 29-57.

1975 Lacy, E., and R. Axel. Analysis of DNA of isolated chromatin subunits. Proc. Natl. Acad. Sci. USA 72: 3978- 3982.

Publications 1976-1985:

1976 Axel, R. and S. Spiegelman. Molecular Virology of Human Neoplasia. In: ONCOLOGIC MEDICINE: Clinical Topics and Practical Management (Alton I. Sutnick, and Paul E. Engstrom, eds.) University Park Press, Baltimore, pp. 1-22.

1976 Axel, R. Transcripition and Chromatin Subunit Structure. In: ADVANCES IN PATHOBIOLOGY, 3: Developmental Genetics (Cecilia M. Fenoglio, Reba Goodman, and Donald West King, eds.) Stratton Intercontinental Medical Book Corp., New York, pp. 27-41.

1976 Axel, R., P. Feigelson, and G. Schutz. Analysis of the complexity and diversity of mRNA from chicken liver and oviduct. Cell 7: 247-254.

1976 Wigler, M., and R. Axel. Nucleosomes in metaphase chromosomes. Nucl. Acids Res. 3: 1463-1471.

1976 Lipchitz, L., and R. Axel. Restriction endonuclease cleavage of satellite DNA in intact bovine nuclei. Cell 9: 355-364.

1976 Axel, R. Dissection of the Eukaryotic Chromosome with Deoxyribonucleases. In: METHODS IN CELL BIOLOGY, 18. Academic Press, New York, pp. 41-54.

1976 Axel, R., and A. Garel. The Structure of the Ovalbumin Gene in Chromatin. In: BIOCHEMICAL ACTIONS OF PROGESTERONE AND PROGESTINS, 286 (Erlio Gurpide, ed.) New York Academy of Sciences, New York, pp. 135-146.

1976 Garel, A., and R. Axel. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc. Natl. Acad. Sci. USA 73: 3966- 3970.

1976 Axel, R. The Structure of Specific Genes in Chromatin. In: PROGRESS IN NUCLEIC ACID RESEARCH, 19. Academic Press, New York, pp. 355-371.

1977 Wigler, M., S. Silverstein, L-S. Lee, A. Pellicer, Y.-c. Cheng, and R. Axel. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11: 223-232.

1977 Garel, A., and R. Axel. The Structure of the Transcriptionally Active Ovalbumin Genes in Chromatin. In: COLD SPRING HARBOR SYMP. QUANT. BIOL. XLII. pp. 701-708.

1977 Dieterich, A., R. Axel, and C. Cantor. Dynamics of Nucleosome Structure Studied by Fluorescence. In: COLD SPRING HARBOR SYMP.QUANT. BIOL. XLII. pp. 199-206.

1977 Silverstein, S., M. Wigler, A. Pellicer, and R. Axel. Identification of Sequences Coding for Thymidine Kinase in Herpes Simplex Virus and Transformed Cell DNA. In: THE THIRD INTERNATIONAL SYMPOSIUM ON ONCOGENESIS AND HERPES VIRUSES (G. de The, ed.) W.H.O., I.A.R.C., pp. 507- 508.

1977 Garel, A., M. Zolan, and R. Axel. Genes transcribed at diverse rates have a similar conformation in chromatin. Proc. Natl. Acad. Sci. USA 74: 4867- 4871.

1978 Garel, A., R.Weinstock, R. Sweet, H. Cedar, and R. Axel. The Organization of the Ovalbumin Gene in the Chromosome. In: THE CELL NUCLEUS, VI (Harris, Bush, ed.) Academic Press, New York, pp. 75-93.

1978 Weinstock, R., R. Sweet, M. Weiss, H. Cedar, and R. Axel. Intragenic DNA spacers interrupt the ovalbumin gene. Proc. Natl. Acad. Sci. USA 75: 1299- 1303.

1978 Pellicer, A., M. Wigler, R. Axel, and S. Silverstein. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell 41: 133-141.

1978 Wigler, M., A. Pellicer, S. Silverstein, and R. Axel. Biochemical transfer of single copy eukaryotic genes using total cellular DNA as donor. Cell 41: 725-731.

1978 Wigler, M., A. Pellicer, R. Axel, and S. Silverstein. Transformation of mammalian cells. In: GENETIC ENGINEERING, PRINCIPLES AND METHODS, 1 (Alexander Hollaender and Jane Setlow, eds.) Plenum Press, New York, pp. 51-72.

1979 Dieterich, A. E., R. Axel, and C. R. Cantor. Salt-induced structural changes of nucleosome core particles. J. Molec. Biol. 129: 587- 602.

1979 Levitt, A., R. Axel, and H. Cedar. Nick translation of active genes in intact nuclei. Developmental Biol. 69: 496-505.

1979 Wigler, M., A. Pellicer, S. Silverstein, R. Axel, G. Urlaub, and L. Chasin. DNA-mediated transfer of the aprt locus into mammalian cells. Proc. Natl. Acad. Sci. USA 76: 1371-1376.

1979 Wigler, M., R. Sweet, G. K. Sim, B. Wold A. Pellicer, E. Lacy, T. Maniatis, S. Silverstein, and R. Axel. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. Cell 16: 777-785.

1979 Wigler, M., R. Sweet , G. K. Sim, B. Wold, A. Pellicer, E. Lacy, T. Maniatis, S. Silverstein, and R. Axel. Transformation of Mammalian Cells with Prokaryotic and Eukaryotic Genes. In: EUKARYOTIC GENE REGULATION, ICN-UCLA Symposia (R. Axel and T. Maniatis, eds.) Academic Press, New York, pp. 457-475.

1979 Wold, B., M. Wigler, E. Lacy, T. Maniatis, S. Silverstein, and R. Axel. Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc. Natl. Acad. Sci. USA 76: 5684-5688.

1980 Wigler, M., M Perucho, D. Kurtz, S. Dana, A. Pellicer, R. Axel, and S. Silverstein. Transformation of mammalian cells with an amplifiable dominant acting gene. Proc. Natl. Acad. Sci. USA 77: 356-3570.

1980 Pellicer, A., E. F. Wagner, A. El Kareh, M. J. Dewey, A. J. Reuser, S. Silverstein, R. Axel, and B. Mintz. Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells. Proc. Natl. Acad. Sci. USA 77: 2098-2102.

1980 Jackson, J., I. Lowy, M. Ostrander, A. Pellicer, J. Roberts, D. Robins, G.-K. Sim, R. Sweet, B. Wold, S. Silverstein, and R. Axel. Stable and Unstable Expression of Genes in DNA Transformed Cells In: MOBILIZATION AND REASSEMBLY OF GENETIC INFORMATION, Miami Winter Symposia, Vol. l (W.A. Scott, R. Werner, D. R. Joseph and J. Schultz, eds.) Academic Press, New York , pp. 181-199.

1980 Sweet, R., J. Jackson, I. Lowy, M. Ostrander, A. Pellicer, J. Roberts, D. Robins, G.-K. Sim, B. Wold, R. Axel, and S. Silverstein. The Expression, Arrangement and Rearrangement of Genes in DNA Transformed Cells. In: GENES, CHROMOSOMES AND NEOPLASIA, The University of Texas System Cancer Center 33rd Annual Symposium on Fundamental Cancer Research, 1980. Williams and Wilkins Co., Baltimore, pp. 205-222.

1980 Pellicer, A., R. Sweet, J. Jackson, I. Lowy, M. Ostrander, J. Roberts, D. Robins, G.-K. Sim, B. Wold, S. Silverstein, and R. Axel. Integration, Expression and Rearrangement of Specific Genes Following DNA- mediated Gene Transfer. In: FLUCTUATIONS, VARIATIONS AND DEVELOPMENT, Institut de la Vie, Springer-Verlag Press.

1980 Pellicer, A., D. Robins, B. Wold, R. Sweet, J. Jackson, I. Lowy, J.M. Roberts, G.K. Sim, S. Silverstein, and R. Axel. Altering genotype and phenotype by DNA mediated gene transfer. Science 209: 1414-1422.

1980 Lowy, I., A. Pellicer, J.F. Jackson, G.K. Sim, S. Silverstein, and R. Axel. Isolation of transforming DNA: cloning the hamster aprt gene. Cell 22: 817-823.

1981 Robins, D.M., S. Ripley, A.S. Henderson, and R. Axel. Transforming DNA integrates into the host chromosome. Cell 23: 29-39.

1981 McKnight, S.L., E.R. Gavis, R. Kingsbury, and R. Axel. Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Proc. Natl. Acad. Sci. USA 78: 7038-7042.

1981 Robins, D. M., R. Axel and A. S. Henderson. Chromosome structure and DNA sequence alterations associated with mutation of transformed genes. J. Molecular and Applied Genetics 1: 191-203.

1981 McKnight, S. L., M. Chao, R. W. Sweet, S. Silverstein, and R. Axel. The Structure and Function of a Eukaryotic Promoter. In: PRIMARY AND TERTIARY STRUCTURE OF NUCLEIC ACIDS AND CANCER RESEARCH, Princess Takamatsu Cancer Research Fund (M. Miwa, S. Nishimura, A. Rich, D. G. Soll and T. Sugimura, eds.) Japan Sci. Soc. Press. Tokyo, pp. 73-85.

1981 McKnight, S. L., M. V. Chao, R. W. Sweet, S. Silverstein, and R. Axel. The Structure and Function of a Eukaryotic Promoter. In: TUMOR CELL HETEROGENEITY: ORIGINS AND IMPLICATIONS, Bristol-Myers Cancer Symposia, Vol. 4 (A. H. Owens, D. S. Coffey, and S. B. Baylin, eds.) Academic Press, New York, pp. 425-440.

1982 McKnight, S. L., M. Chao, R. W. Sweet, S. Silverstein, and R. Axel. Transcriptional Control of Transformed Genes. In: ONCODEVELOPMENTAL BIOLOGY AND MEDICINE, 9th Annual Meeting (F.L. Lorscheider, ed.) Elsevier Biomedical Press, Amsterdam.

1982 Scheller, R.H., J.F. Jackson, L.B. McAllister, J.H. Schwartz, E.R. Kandel, and R. Axel. A family of genes that codes for ELH, a neuropeptide which elicits a stereotyped pattern of behavior in Aplysia. Cell 28: 707-719.

1982 Roberts, J.M., and R. Axel. Gene amplification and gene correction in somatic cells. Cell 29: 109-119.

1982 Chao, M.V., P. Mellon, B. Wold, T. Maniatis, and R. Axel. Regulation of Globin Genes Introduced into MEL Cells. In: PROCEEDINGS OF THE SYMPOSIUM ON HEMOGLOBIN SYNTHESIS, The University of Chicago, Oct., 1981 (E. Goldwasser, ed.) Elsevier/North-Holland, New York.

1982 Corces, V., A. Pellicer, R. Axel, S.-Y. Mei, and M. Meselson. Approximate Localization of Sequences Controlling Transcription of a Drosophila Heat Shock Gene. In: HEAT SHOCK: FROM BACTERIA TO MAN (M. Schlesinger, A. Tissieres and M. Ashburne, eds.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 27-34.

1982 Robins, D.M., I. Paek, P. H. Seeburg, and R. Axel. The regulated expression of human growth hormone genes in mouse cells. Cell 29: 623-631.

1982 Robins, D. M., I. Paek, R. Axel, and P. Seeburg. Expression of the Human Growth Hormone Gene is Regulated in Mouse Cells. In: FROM GENE TO PROTEIN: TRANSLATION INTO BIOTECHNOLOGY, Miami Winter Symposia (F. Ahmad, J. Schultz, E. E. Smith and W.J. Whelan, eds.) Academic Press, New York, pp. 275-288.

1982 Sweet, R. W., M. V. Chao, and R. Axel. The structure of the thymidine kinase gene promoter: Nuclease hypersensitivity correlates with expression. Cell 31: 347-353.

1982 Robins, D. M., I. Paek, P.H. Seeburg, and R. Axel. Regulation of the Human Growth Hormone Gene in Mouse Cells. In: GENE REGULATION, Cetus- UCLA Symposia, Keystone, Colorado (B. O'Malley, ed.) Academic Press, N.Y., pp. 253-265.

1983 Scheller, R. H., J. F. Jackson, L. B. McAllister, B. S. Rothman, E. Mayeri, and R. Axel. A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell 32: 7-22.

1983 Chao, M. V., P. Mellon, P. Charney, T. Maniatis, and R. Axel. The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell 32: 483-493.

1983 Roberts, J. M., L. B. Buck, and R. Axel. The structure of amplified DNA. Cell 33: 53-63.

1983 McAllister, L. B., R. H. Scheller, E. R. Kandel, and R. Axel. In situ hybridization to study the origin and fate of identified neurons. Science 222: 800-808.

1983 Buck, L., R. Stein, M. Palazzolo, D. Anderson, and R. Axel. Gene Expression and the Diversity of Identified Neurons. In: COLD SPRING HARBOR SYMP. QUANT. BIOL., vol. XLVIII, MOLECULAR NEUROBIOLOGY, pp. 485-492.

1983 Claudio, T., M. Palazzolo, and R. Axel. Cloning and Transfer of Acetylcholine Receptor Genes. Soc. for Neuroscience, 1983 Short Course Syllabus.

1984 Scheller, R., and R. Axel. Genes, Peptides and Behavior. Scientific American 250: 53-62.

1984 McAllister, L. B., R. H. Scheller, E. R. Kandel, and R. Axel. The Expression of Neuropeptide Genes in Developing and Adult Neurons. In: ARDEN HOUSE SYMPOSIUM, TRANSFER AND EXPRESSION OF EUKARYOTIC GENES, pp. 153-168.

1984 Charney, P., R. Treisman, P. Mellon, M. Chao, R. Axel, and T. Maniatis. Differences in human a- and b-globin gene expression in mouse erythroid cells: The role of intragenic sequences. Cell 38: 251-263.

1985 Littman, D. R., Y. Thomas, P. J. Maddon, L.A. Chess, and R. Axel. The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes. Cell 40: 237-246.

1985 Lemke, G., and R. Axel. Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin. Cell 40: 501-508.

1985 Madaule, P., and R. Axel, A novel ras-related gene family. Cell 41: 31-40.

1985 Pernis, B., and R. Axel. A one and a half receptor model for MHC- restricted antigen recognition by T lymphocytes. Cell 41: 13-16.

1985 Maddon, P. J., D. R. Littman, M. Godfrey, D. E. Maddon, L. Chess, and R. Axel. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: A new member of the immunoglobulin gene family. Cell 42: 93-104.

1985 Anderson, D. J., and R. Axel. Molecular probes for the development and plasticity of neural crest derivatives. Cell 42: 649-662.

1985 Axel, R. Neuropeptide Genes Mediating Complex Behavior in Aplysia. In: THE HARVEY LECTURES, Series 79, Academic Press, New York, pp. 1- 30.

1985 Axel, R. Genes Modulating Behavior in Simple Organisms; "The Story of a Snail". In, EDITIONS HOLOGRAMME, Paris, France (ed. E. Antebi) pp. 62-67.

1985 Anderson, D. J., R. Stein, and R. Axel. Gene Expression in Differentiating and Transdifferentiating Neural Crest Cells. In: COLD SPRING HARBOR SYMP. QUANT. BIOL., MOLECULAR BIOLOGY OF DEVELOPMENT, Vol. L, pp 855 - 863.

Publications 1986-1995:

1986 Benezra, R., C. R. Cantor, and R. Axel. Nucleosomes are phased along the mouse beta-major globin gene in erythroid and nonerythroid cells. Cell 44: 697-704.

1986 Argarana, C. E., I. D. Kuntz, S. Birken, R. Axel, and C. R. Cantor. Molecular cloning and nucleotide sequence of the streptavidin gene. Nucleic Acids Res. 14: 1871-1882.

1986 Isobe, M., K. Huebner, P.J. Maddon, D. R. Littman, R. Axel, and C. M. Croce. The gene encoding the T cell surface protein T4 is located on human chromosome 12. Proc. Natl. Acad. Sci. USA 83: 4399-4402.

1986 Dalgleish, A. G., P.J. Maddon, D. R. Littman, P. R. Clapham, M. Godfrey, L. Chess, R. A. Weiss, J. S. McDougal, and R. Axel. T4: A T Cell Surface Protein Mediating Cell-Cell and Cell-AIDS Virus Interactions. In, PROCEEDINGS OF THE 4TH ANNUAL SMITH, KLINE & FRENCH SYMPOSIA.

1986 McDougal, J. S., P. J. Maddon, A G. Dalgleish, P. R. Clapham, D. R. Littman, M. Godfrey, D. E. Maddon, L. Chess, R. A. Weiss, and R. Axel. The T4 Glycoprotein is a Cell Surface Receptor for the AIDS Virus. In: PROCEEDINGS COLD SPRING HARBOR SYMP. QUANT. BIOL., MOLECULAR BIOLOGY OF HOMO SAPIENS, Vol. 51, pp 703-711.

1986 Maddon, P J., A. G. Dalgleish, J. S. McDougal , P. R. Clapham, R. A. Weiss, and R. Axel. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333-348.

1986 Anderson, D., and R. Axel. A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids. Cell 47: 1079-1090.

1987 Paek, I., and R. Axel. Glucocorticoids enhance the stability of human growth hormone mRNA. Molecular and Cellular Biol. 7: 1496-1507.

1987 Madaule, P., R. Axel, and A. M. Myers. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 84: 779-783.

1987 Buck, L. B. J.M. Bigelow, and R. Axel. Alternative splicing in individual Aplysia neurons generates neuropeptide diversity. Cell 51: 127-133.

1987 Gay, D., P. J. Maddon, R. Sekaly, M. A. Talle, M. Godfrey, E. Long, G. Goldstein, L., Chess, R. Axel, J. Kappler, and P. Marrack. Functional interaction between human T cell protein CD4 and the major histocompatibility complex HLA-DR Antigen. Nature 328: 626-629.

1987 Maddon, P. J., S. M. Molineaux, D. E. Maddon, K. A. Zimmerman, M. Godfrey, F. W. Alt, L. Chess, and R. Axel. Structure and expression of the human and mouse T4 genes. Proc. Natl. Acad. Sci. USA 84: 9155-9159.

1988 Deen, K. C., J. S. McDougal, R. Inacker, G. F.-Wasserman, J. Arthos, J. Rosenberg, P. J. Maddon, R. Axel, and R. W. Sweet. A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature 331: 82-84.

1988 Maddon, P. J., J. S. McDougal, A. G. Dalgleish, P. R. Clapham, D. R Littman, M. Godfrey, D. E. Maddon, L. Chess, R. A. Weiss, and R. Axel. T4: A Receptor Mediating Cell-Cell and Cell-Virus Interactions. In, PROCEEDINGS OF THE YAKULT INTERNATIONAL SCIENCE SYMPOSIUM, MOLECULAR NEUROSCIENCE, Yakult Honshu Co., Tokyo, pp. 47-67.

1988 Julius, D., A. B. MacDermott, R. Axel, and T. M. Jessell. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241: 558-564.

1988 Maddon, P. J., J. S. McDougal, P.R. Clapham, A. G. Dalgleish, S. Jamal, R. A. Weiss, and R. Axel. HIV infection does not require endocytosis of its receptor, CD4. Cell 54: 865-874.

1988 Julius, D., A. MacDermott, T. Jessell, K. Huang, S. Molineaux, I. Schieren, and R. Axel. Functional Expression of the 5HTlc Receptor in Neuronal and Non-neuronal Cells. In: COLD SPRING HARBOR SYMP. QUANT. BIOL., MOLECULAR BIOLOGY OF SIGNAL TRANSDUCTION, Vol. 53, pp. 385-393.

1989 Arthos, J., K. C. Deen, M.A. Chaikin, J. A. Fornwald, G. Sathe, Q. J. Sattentau, P. R. Clapham, R. A. Weiss, J. S. McDougal, C. Pietropaolo, P. J. Maddon, A. Truneh, R. Axel, and R. W. Sweet. Identification of the residues in human CD4 critical for the binding of HIV. Cell 57: 469-481.

1989 Julius, D., T. J. Livelli, T. M. Jessell, and R., Axel. Ectopic expression of the serotonin lc receptor and the triggering of malignant transformation. Science 244: 1057-1062.

1989 Hen, R., R. Axel, and S. Obici. Activation of the beta-2-adrenergic receptor promotes growth and differentiation in thyroid cells. Proc. Natl. Acad. Sci. USA 86: 4785-4788.

1989 Molineaux, S. M., T. M. Jessell, R. Axel, and D. Julius. The 5-HTlc receptor is a prominent serotonin subtype in the central nervous system. Proc. Natl. Acad. Sci. USA 86: 6793-6797.

1989 Julius, D., K. M. Huang, T. J. Livelli, R. Axel, and T. M. Jessell, The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc. Natl. Acad. Sci. USA 87: 928-932.

1989 Sweet, R., J. Arthos, K. Deen, M. A. Chaikin, J. A. Fornwald, G.M. Sathe, A. Truneh, M. Rosenberg, Q. J. Sattentau, P. R. Clapham, R. A. Weiss, J. S. McDougal, C. Pietropaolo, P. J. Maddon, and R. Axel. Recognition of CD4 by the AIDS virus: Inhibition by soluble CD4 and analysis of the virus binding site. In, FRONTIERS OF CHEMISTRY: BIOTECHNOLOGY (R.E. Stobauch, ed.) pp. 151-167.

1990 Arthos, J., K. C. Deen, M. A. Chaikin, J. Fornwald, G. M. Sathe, P. Clapham, R. Weiss, J. S. McDougal, C. Pietropaolo, P. J. Maddon,, A. Truneh, R. Axel, and R. Sweet. Analysis of the HIV Envelope Binding Domain on CD4 through Site-directed Mutagenesis. In: PROCEEDINGS, UCLA SYMPOSIUM ON MOLECULAR AND CELLULAR BIOLOGY: HUMAN RETROVIRUSES. NEW SERIES, Alan R. Liss. Inc., New York, NY, p. 171 - 179.

1990 Robey, E., and R. Axel. CD4: Collaborator in Immune Recognition and HIV Infection. Minireview. Cell 60: 697-700.

1990 Kwong, P. D., S. Ryu, W. A. Hendrickson, R. Axel, R.M. Sweet, G. Folena- Wasserman, P. Hensley, and R. W. Sweet. Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals. Proc. Natl. Acad. Sci. USA 87: 6423-6427.

1990 Nakanishi, N., N. A. Shneider, and R. Axel. A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron 5: 569-581.

1990 Ryu, S.-E., P. D. Kwong, A. Truneh, T. G. Porter, J. Arthos, M. Rosenberg, X. Dai. N-h Xuong, R. Axel, R. W. Sweet, and W. A. Hendrickson. Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature 348: 419-426.

1991 Robey, E., B. J. Fowlkes, J. W. Gordon, D. Kioussis, H. Von Boehme, F. Ramsdell, and R. Axel. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64: 99-107.

Publications 1996-present:

1996 Axel, R. The Molecular Biology of Smell. In: Proceedings of the Biotechnology Colloquium at the New York Academy of Sciences (October 1995), pp. 1-16.

1996 Mombaerts P., F. Wang, C. Dulac, R. Vassar, S.K. Chao, A. Nemes, M. Mendelsohn, J. Edmondson, and R. Axel. The Molecular Biology of Olfactory Perception. In: Proceedings Cold Spring Harbor Symposium, Vol. LXI: Function and Dysfunction in the Nervous System, pp. 135-145.

1996 Mombaerts, P., F. Wang, C. Dulac, S.K. Chao, A. Nemes, M. Mendelsohn, J. Edmondson, and R. Axel. Visualizing an olfactory sensory map. Cell 87: 675-686.

1997 Amrein, H., and R. Axel. Genes expressed solely in male neurons of the adult fly. Cell 88: 459-469.

1997 Yang, J.-H., P. Sklar, R. Axel, and T. Maniatis. Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proc. Natl. Acad. Sci. USA 94: 4354-4359.

1998 Belluscio L, Gold GH, Nemes, A, Axel R. Mice deficient in G(olf) are anosmic. Neuron 20:69-81.

1998 Wang F, Nemes A, Mendelsohn M, and Axel R. Odorant Receptors Govern the Formation of a Precise Topographic Map. Cell 93:47-60

1998 Dulac C and Axel R. Expression of candidate pheromone receptor genes in vomeronasal neurons. Chemical Senses 23:467-475

1998 Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S, Meneses J, Pedersen R, Axel R, Rubenstein JL. An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 21:1273-1282

1999 Vosshall LB, Amrein H, Morozov P, Rzhetsky A, and Axel R. A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna. Cell, 96:725-736.

1999 Belluscio L, Koentges G, Axel R, Dulac C A map of pheromone receptor activation in the mammalian brain. Cell, 97:209-220.

1999 Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc. Natl. Acad. Sci. USA 96:5129-5134.

2000 Lin DM, Wang F, Lowe G, Gold GH, Axel R, Ngai J, Brunet L Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron 26:69-80.

2000 Vosshall LB, Wong AM, and Axel R. An Olfactory Sensory Map in the Fly Brain. Cell, 102:147-159.

2001 Gogos JA, Osborne J, Nemes A, Mendelsohn M, Axel R. Related Articles Genetic ablation and restoration of the olfactory topographic map. Cell, 103(4):609-620.

2001 Scott K, Brady R Jr, Cravchik A, Morozov P, Rzhetsky A, Zuker C, Axel R. A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell, 104(5):661-673.

2001 Lane RP, Cutforth T, Young J, Athanasiou M, Friedman C, Rowen L, Evans G, Axel R, Hood L, Trask BJ. Genomic analysis of orthologous mouse and human olfactory receptor loci. Proc Natl Acad Sci U S A, 98(13):7390-7395.

2002 Lane RP, Cutforth T, Axel R, Hood L, Trask BJ. Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion. Proc Natl Acad Sci U S A, 99(1):291-296.

2002 Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R. Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A, 99(9):6376-6381.

2002 Wong AM, Wang JW, Axel R. Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum. Cell, 109(2):229-241.

2002 Tasic B, Nabholz CE, Baldwin KK, Kim Y, Rueckert EH, Ribich SA, Cramer P, Wu Q, Axel R, Maniatis T. Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Mol Cell, 10(1):21-33.